Antiarrhythmics

Drug Class Common Versions Mechanism of Action  Indications Rehab Implications
(Class 1) Sodium Channel Blocker Lidocane, Flecanide Reduce phase 0 depolarization and conduction velocity in non-nodal tissue (ventricles) Vtach and Vfib Diarrhea, nausea, HA, Long QT syndrome
(Class 2) Beta Blocker Propanolol, Metoprolol Tartate Blocks Beta 1 receptors reducing SA node rate, AV conduction and increasing action potential duration Atrial Arrhytmias and Vfib Suppressed HR and BP response to activity
(Class 3) Pottassium Channel Blocker Sotalol, Amiodarone*** Delays phase 3 repolarization thus increasing effective refractory period SVT, Vtach, Vfib, Afib Increases QT interval, Amiodarone May cause skin to turn blue and cause ILD
(Class 4) Calcium Channel Blocker Verapamil, Diltiazem Blocks Ca2+ channels, reduces SA conduction and rate SVT Suppressed HR and BP response to activity
(Class 5) Other (Purine Nucleoside) Adenosine Reduces AV node conduction SVT  HA, Flushing,
(Class 5) Other (Anti-cholinergic) Atropine Reduces vagal tone Symptomatic Bradycardia
(Class 5) Other (IV Electrolyte) Magnesium Sulfate Prolongs SA node depolarzation, reduces SA and AV node automaticity and conduction Torades de Pointes

***Amiodarone actually has Beta Blocker, Ca2+ and Sodium Channel blocking properties

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